Research Article

The genetic architecture of the human cerebral cortex

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Science  20 Mar 2020:
Vol. 367, Issue 6484, eaay6690
DOI: 10.1126/science.aay6690

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Genetic determination of cortex structure

The human cerebral cortex is important for cognition, and it is of interest to see how genetic variants affect its structure. Grasby et al. combined genetic data with brain magnetic resonance imaging from more than 50,000 people to generate a genome-wide analysis of how human genetic variation influences human cortical surface area and thickness. From this analysis, they identified variants associated with cortical structure, some of which affect signaling and gene expression. They observed overlap between genetic loci affecting cortical structure, brain development, and neuropsychiatric disease, and the correlation between these phenotypes is of interest for further study.

Science, this issue p. eaay6690

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